| ID Source | ID |
|---|---|
| PubMed CID | 5715152 |
| CHEMBL ID | 196470 |
| CHEBI ID | 190617 |
| SCHEMBL ID | 1514609 |
| Synonym |
|---|
| 4,5-diphenyl-1h-pyrazolo[3,4-c]pyridazin-3-ol |
| pyrazolopyridazine 2a |
| bdbm7479 |
| SR-01000640965-1 |
| OPREA1_276449 |
| HMS1664B08 |
| CHEMBL196470 |
| CHEBI:190617 |
| 4,5-diphenyl-1,2-dihydropyrazolo[3,4-c]pyridazin-3-one |
| 4,5-diphenyl-2,3-dihydro-1h-pyrazolo[3,4-c]pyridazin-3-one |
| CCG-51676 |
| SCHEMBL1514609 |
| Class | Description |
|---|---|
| ring assembly | Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved. |
| pyridazines | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0002 | 1.3173 | 10.0000 | AID1796046 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 (µMol) | 50.0000 | 0.0040 | 2.1093 | 9.4000 | AID1796046 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0000 | 0.4830 | 8.8000 | AID1796046 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 (µMol) | 50.0000 | 0.0040 | 2.1093 | 9.4000 | AID1796046 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID255866 | Cytotoxic effect against human cervical carcinoma cell line (HeLa) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. |
| AID255867 | Cytotoxic effect against human prostate carcinoma cell line (PC-3) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. |
| AID254800 | Inhibitory concentration against CDK1/Cyclin B complex from Marthasterias glacialis M-phase oocytes | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. |
| AID255864 | Cytotoxic effect against human colon carcinoma cell line (HT-29) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. |
| AID1796046 | Kinase Inhibition Assay from Article 10.1021/jm058013g: \\Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.\\ | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.68) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||